THE EFFECT OF BETEL LEAF EXTRACT SPRAY ON HISTOPATHOLOGY OF WOUND HEALING

Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known contain compounds that may be used wound healers. The purpose of this study was test the spray activity betel extract (Piper betle L) in healing acute wounds male Balb/C mice. Spray formula made with various concentrations by 3% (S1), 5% (S2) and 7% (S3). 15 mice divided into 5 groups S1, S2, S3, P (positive control), C (negative control). Interventions observations were carried out for 14 days. results observational analysis calculating ratio area then One Way Anova Post Hoc Tukey Cramer test. showed concentration significantly different from (p>0.05). conclusion sprays 3%, 5%, an healer, best shown at 7%.